20-22 Exeter Owen Farrell and Luke Cowan-Dickie of England were injured as Saracens defeated Exeter.
Owen Farrell and Luke Cowan-Dickie, both England players, were injured in Saracens' 22-20 victory over Exeter in the Gallagher Premiership on Saturday.
Alex Goode fired Saracens to their sixth consecutive Gallagher Premiership win, scoring a penalty with the final kick of the game to beat Exeter by two points at Sandy Park.
However, England suffered a double fitness scare as Saracens and England fly-half Owen Farrell left the game midway through the second period after taking a blow to the head, and Exeter hooker Luke Cowan-Dickie had to leave at halftime due to a knee injury.
Henry Slade of the Chiefs appeared to have responded to his exclusion from England's Autumn Nations Series squad by kicking a penalty four minutes from time.
But Goode, who came on as a replacement for Farrell and made his 338th Saracens first-team appearance, came up trumps with the clock ticking down.
Farrell and England teammate Mako Vunipola were both yellow carded, with Vunipola receiving a sin-binning for collapsing an Exeter driving maul and allowing a penalty try in the process.
But Saracens kept their cool on a testing afternoon, with flanker Theo McFarland scoring a first-half try, Farrell converting and kicking two penalties, full-back Elliot Daly adding two long-range strikes, and Goode scoring late.
Despite a few lapses in discipline, the visitors put on a confident performance, underlining their title credentials in pursuit of the Premiership silverware they last won three years ago.
Exeter had their chances, but not enough to upset Saracens' well-oiled machine. The tense finish came after centre Slade converted No. 8 Jacques Vermeuelen's 71st-minute try, which came after an early penalty and the penalty try.
Saracens had been their own worst enemy in the first half, having a penalty reversed for foul play and then losing Farrell to a yellow card in the sixth minute.
The Saracens captain illegally impeded Chiefs wing Jack Nowell, and referee Tom Foley, whose patience was already wearing thin, ejected Farrell.
Exeter couldn't capitalize on their one-man advantage, as Chiefs' Scotland international full-back Stuart Hogg left for a head injury assessment, with Joe Simmonds replacing him.
Following a scoreless first quarter, Slade put Exeter ahead with a 48-metre penalty, but Saracens responded clinically.
Daly and wing Max Malins worked well together to test Exeter's defense, and before the Chiefs could regroup, McFarland surged through a gap to score from his team's first attack, which Farrell converted.
As defenses dominated, Hogg returned to the action and proved to be Exeter's most dangerous attacker.
Exeter took the lead again just before halftime when referee Foley issued another yellow card, this time to Vunipola.
The visitors' luck worsened when Vunipola was not only sin-binned for bringing down an ominous driving maul, but his actions were also deemed worthy of a penalty try.
Exeter's narrow lead, however, was short-lived, as Daly converted a 40-metre penalty into the wind to make the score 10-10 at halftime.
Cowan-Dickie did not return for the second period, having been replaced by Jack Yeandle, and Saracens took the lead again thanks to a Farrell penalty after Chiefs fly-half Harvey Skinner was yellow-carded for a technical infringement.
There was no letup in the intensity, and both coaches began making substitutions ahead of the fourth quarter, though Hogg's 54th-minute exit saw him shake his head in disapproval as he walked off the field.
Farrell increased Saracens' lead with a 30-metre penalty, but he was forced off after 61 minutes due to an accidental knee to the head, and Goode took his place.
Following Farrell's penalty double, Daly added a penalty from five metres inside his own half, only for Exeter to respond when Vermeulen touched down following Skinner's half-break.
After Slade's three-pointer, Goode had the final say as Saracens claimed their first Premiership away win against Exeter since 2016.